Safest drugstore weight loss supplement

Natural Medicines says that bitter orange is "possibly unsafe" when taken by mouth as a supplement, and there's not enough evidence to know if it works for weight loss.

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Natural Medicines says that bitter orange is "possibly unsafe" when taken by mouth as a supplement, and there's not enough evidence to know if it works for weight loss.

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Bitter orange is a currently available herbal stimulant used in some weight-loss supplements and is often called an ephedra substitute. The active ingredient in bitter orange has chemical properties and actions that are similar to ephedra and may be associated with similar adverse effects.

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